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For wet paint: rinse under cold running water from the back of the fabric, then rub in a little dish soap and keep flushing until the water runs clear. For dried paint: soak the spot in rubbing alcohol, work it with an old toothbrush, and repeat.
The two rules that decide whether you save the garment:
Removing wet acrylic paint:
Removing dried acrylic paint:
Other solvents that work, in rough order of strength:
Always test any solvent on a hidden seam or inside hem first to check it doesn't lift the fabric's colour.
By fabric type:
If a faint shadow remains after everything, try soaking the garment in oxygen-based bleach (like OxiClean) in cold water for a few hours before washing again. On white cotton only, diluted chlorine bleach is an option.
Preventing it next time: wear an apron or old clothes, keep a damp cloth beside you while painting, and rinse splashes the moment they happen — thirty seconds of rinsing while wet saves an hour of scrubbing later.